Outcome of intracerebral hemorrhage associated with different oral anticoagulants
Identifieur interne : 000667 ( Main/Exploration ); précédent : 000666; suivant : 000668Outcome of intracerebral hemorrhage associated with different oral anticoagulants
Auteurs : Duncan Wilson ; David J. Seiffge ; Christopher Traenka ; Ghazala Basir ; Jan C. Purrucker ; Timolaos Rizos ; Oluwaseun A. Sobowale ; Hanne Sallinen ; Shin-Joe Yeh ; Teddy Y. Wu ; Marc Ferrigno ; Rik Houben ; Floris H. B. M. Schreuder ; Luke A. Perry ; Jun Tanaka ; Marion Boulanger ; Rustam Al-Shahi Salman ; Hans R. J Ger ; Gareth Ambler ; Clare Shakeshaft ; Yusuke Yakushiji ; Philip M. C. Choi ; Julie Staals ; Charlotte Cordonnier ; Jiann-Shing Jeng ; Roland Veltkamp ; Dar Dowlatshahi ; Stefan T. Engelter ; Adrian R. Parry-Jones ; Atte Meretoja ; David J. WerringSource :
- Neurology [ 0028-3878 ] ; 2017.
Descripteurs français
- KwdFr :
- Administration par voie orale, Analyse de survie, Analyse multivariée, Anticoagulants (administration et posologie), Enregistrements, Femelle, Humains, Hémorragie cérébrale (), Hémorragie cérébrale (anatomopathologie), Hémorragie cérébrale (mortalité), Hémorragie cérébrale (traitement médicamenteux), Modèles de hasards proportionnels, Modèles logistiques, Mâle, Résultat thérapeutique, Vitamine K (antagonistes et inhibiteurs), Échelle de Glasgow, Études prospectives, Études rétrospectives.
- MESH :
- administration et posologie : Anticoagulants.
- anatomopathologie : Hémorragie cérébrale.
- antagonistes et inhibiteurs : Vitamine K.
- mortalité : Hémorragie cérébrale.
- traitement médicamenteux : Hémorragie cérébrale.
- Administration par voie orale, Analyse de survie, Analyse multivariée, Enregistrements, Femelle, Humains, Hémorragie cérébrale, Modèles de hasards proportionnels, Modèles logistiques, Mâle, Résultat thérapeutique, Échelle de Glasgow, Études prospectives, Études rétrospectives.
English descriptors
- KwdEn :
- Administration, Oral, Anticoagulants (administration & dosage), Cerebral Hemorrhage (drug therapy), Cerebral Hemorrhage (mortality), Cerebral Hemorrhage (pathology), Cerebral Hemorrhage (surgery), Female, Glasgow Coma Scale, Humans, Logistic Models, Male, Multivariate Analysis, Proportional Hazards Models, Prospective Studies, Registries, Retrospective Studies, Survival Analysis, Treatment Outcome, Vitamin K (antagonists & inhibitors).
- MESH :
- chemical , administration & dosage : Anticoagulants.
- chemical , antagonists & inhibitors : Vitamin K.
- drug therapy : Cerebral Hemorrhage.
- mortality : Cerebral Hemorrhage.
- pathology : Cerebral Hemorrhage.
- surgery : Cerebral Hemorrhage.
- Administration, Oral, Female, Glasgow Coma Scale, Humans, Logistic Models, Male, Multivariate Analysis, Proportional Hazards Models, Prospective Studies, Registries, Retrospective Studies, Survival Analysis, Treatment Outcome.
Abstract
In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non–vitamin K antagonist oral anticoagulation–related ICH (NOAC-ICH) and vitamin K antagonist–associated ICH (VKA-ICH).
We compared all-cause mortality within 90 days for NOAC-ICH and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular hemorrhage volume; and intracranial surgery. We addressed heterogeneity using a shared frailty term. Good functional outcome was defined as discharge modified Rankin Scale score ≤2 and investigated in multivariable logistic regression. ICH volume was measured by ABC/2 or a semiautomated planimetric method. HE was defined as an ICH volume increase >33% or >6 mL from baseline within 72 hours.
We included 500 patients (97 NOAC-ICH and 403 VKA-ICH). Median baseline ICH volume was 14.4 mL (interquartile range [IQR] 3.6–38.4) for NOAC-ICH vs 10.6 mL (IQR 4.0–27.9) for VKA-ICH (
In our international collaborative multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH.
Url:
DOI: 10.1212/WNL.0000000000003886
PubMed: 28381513
PubMed Central: 5409844
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 002797
- to stream Pmc, to step Curation: 002647
- to stream Pmc, to step Checkpoint: 000164
- to stream PubMed, to step Corpus: 000C27
- to stream PubMed, to step Curation: 000C24
- to stream PubMed, to step Checkpoint: 000C24
- to stream Ncbi, to step Merge: 004593
- to stream Ncbi, to step Curation: 004593
- to stream Ncbi, to step Checkpoint: 004593
- to stream Main, to step Merge: 000662
- to stream Main, to step Curation: 000667
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Outcome of intracerebral hemorrhage associated with different oral anticoagulants</title><author><name sortKey="Wilson, Duncan" sort="Wilson, Duncan" uniqKey="Wilson D" first="Duncan" last="Wilson">Duncan Wilson</name></author><author><name sortKey="Seiffge, David J" sort="Seiffge, David J" uniqKey="Seiffge D" first="David J." last="Seiffge">David J. Seiffge</name></author><author><name sortKey="Traenka, Christopher" sort="Traenka, Christopher" uniqKey="Traenka C" first="Christopher" last="Traenka">Christopher Traenka</name></author><author><name sortKey="Basir, Ghazala" sort="Basir, Ghazala" uniqKey="Basir G" first="Ghazala" last="Basir">Ghazala Basir</name></author><author><name sortKey="Purrucker, Jan C" sort="Purrucker, Jan C" uniqKey="Purrucker J" first="Jan C." last="Purrucker">Jan C. Purrucker</name></author><author><name sortKey="Rizos, Timolaos" sort="Rizos, Timolaos" uniqKey="Rizos T" first="Timolaos" last="Rizos">Timolaos Rizos</name></author><author><name sortKey="Sobowale, Oluwaseun A" sort="Sobowale, Oluwaseun A" uniqKey="Sobowale O" first="Oluwaseun A." last="Sobowale">Oluwaseun A. Sobowale</name></author><author><name sortKey="Sallinen, Hanne" sort="Sallinen, Hanne" uniqKey="Sallinen H" first="Hanne" last="Sallinen">Hanne Sallinen</name></author><author><name sortKey="Yeh, Shin Joe" sort="Yeh, Shin Joe" uniqKey="Yeh S" first="Shin-Joe" last="Yeh">Shin-Joe Yeh</name></author><author><name sortKey="Wu, Teddy Y" sort="Wu, Teddy Y" uniqKey="Wu T" first="Teddy Y." last="Wu">Teddy Y. Wu</name></author><author><name sortKey="Ferrigno, Marc" sort="Ferrigno, Marc" uniqKey="Ferrigno M" first="Marc" last="Ferrigno">Marc Ferrigno</name></author><author><name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name></author><author><name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H. B. M." last="Schreuder">Floris H. B. M. Schreuder</name></author><author><name sortKey="Perry, Luke A" sort="Perry, Luke A" uniqKey="Perry L" first="Luke A." last="Perry">Luke A. Perry</name></author><author><name sortKey="Tanaka, Jun" sort="Tanaka, Jun" uniqKey="Tanaka J" first="Jun" last="Tanaka">Jun Tanaka</name></author><author><name sortKey="Boulanger, Marion" sort="Boulanger, Marion" uniqKey="Boulanger M" first="Marion" last="Boulanger">Marion Boulanger</name></author><author><name sortKey="Al Shahi Salman, Rustam" sort="Al Shahi Salman, Rustam" uniqKey="Al Shahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name></author><author><name sortKey="J Ger, Hans R" sort="J Ger, Hans R" uniqKey="J Ger H" first="Hans R." last="J Ger">Hans R. J Ger</name></author><author><name sortKey="Ambler, Gareth" sort="Ambler, Gareth" uniqKey="Ambler G" first="Gareth" last="Ambler">Gareth Ambler</name></author><author><name sortKey="Shakeshaft, Clare" sort="Shakeshaft, Clare" uniqKey="Shakeshaft C" first="Clare" last="Shakeshaft">Clare Shakeshaft</name></author><author><name sortKey="Yakushiji, Yusuke" sort="Yakushiji, Yusuke" uniqKey="Yakushiji Y" first="Yusuke" last="Yakushiji">Yusuke Yakushiji</name></author><author><name sortKey="Choi, Philip M C" sort="Choi, Philip M C" uniqKey="Choi P" first="Philip M. C." last="Choi">Philip M. C. Choi</name></author><author><name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name></author><author><name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name></author><author><name sortKey="Jeng, Jiann Shing" sort="Jeng, Jiann Shing" uniqKey="Jeng J" first="Jiann-Shing" last="Jeng">Jiann-Shing Jeng</name></author><author><name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name></author><author><name sortKey="Dowlatshahi, Dar" sort="Dowlatshahi, Dar" uniqKey="Dowlatshahi D" first="Dar" last="Dowlatshahi">Dar Dowlatshahi</name></author><author><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T." last="Engelter">Stefan T. Engelter</name></author><author><name sortKey="Parry Jones, Adrian R" sort="Parry Jones, Adrian R" uniqKey="Parry Jones A" first="Adrian R." last="Parry-Jones">Adrian R. Parry-Jones</name></author><author><name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name></author><author><name sortKey="Werring, David J" sort="Werring, David J" uniqKey="Werring D" first="David J." last="Werring">David J. Werring</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28381513</idno><idno type="pmc">5409844</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5409844</idno><idno type="RBID">PMC:5409844</idno><idno type="doi">10.1212/WNL.0000000000003886</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">002797</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">002797</idno><idno type="wicri:Area/Pmc/Curation">002647</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">002647</idno><idno type="wicri:Area/Pmc/Checkpoint">000164</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000164</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000C27</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000C27</idno><idno type="wicri:Area/PubMed/Curation">000C24</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000C24</idno><idno type="wicri:Area/PubMed/Checkpoint">000C24</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000C24</idno><idno type="wicri:Area/Ncbi/Merge">004593</idno><idno type="wicri:Area/Ncbi/Curation">004593</idno><idno type="wicri:Area/Ncbi/Checkpoint">004593</idno><idno type="wicri:doubleKey">0028-3878:2017:Wilson D:outcome:of:intracerebral</idno><idno type="wicri:Area/Main/Merge">000662</idno><idno type="wicri:Area/Main/Curation">000667</idno><idno type="wicri:Area/Main/Exploration">000667</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Outcome of intracerebral hemorrhage associated with different oral anticoagulants</title><author><name sortKey="Wilson, Duncan" sort="Wilson, Duncan" uniqKey="Wilson D" first="Duncan" last="Wilson">Duncan Wilson</name></author><author><name sortKey="Seiffge, David J" sort="Seiffge, David J" uniqKey="Seiffge D" first="David J." last="Seiffge">David J. Seiffge</name></author><author><name sortKey="Traenka, Christopher" sort="Traenka, Christopher" uniqKey="Traenka C" first="Christopher" last="Traenka">Christopher Traenka</name></author><author><name sortKey="Basir, Ghazala" sort="Basir, Ghazala" uniqKey="Basir G" first="Ghazala" last="Basir">Ghazala Basir</name></author><author><name sortKey="Purrucker, Jan C" sort="Purrucker, Jan C" uniqKey="Purrucker J" first="Jan C." last="Purrucker">Jan C. Purrucker</name></author><author><name sortKey="Rizos, Timolaos" sort="Rizos, Timolaos" uniqKey="Rizos T" first="Timolaos" last="Rizos">Timolaos Rizos</name></author><author><name sortKey="Sobowale, Oluwaseun A" sort="Sobowale, Oluwaseun A" uniqKey="Sobowale O" first="Oluwaseun A." last="Sobowale">Oluwaseun A. Sobowale</name></author><author><name sortKey="Sallinen, Hanne" sort="Sallinen, Hanne" uniqKey="Sallinen H" first="Hanne" last="Sallinen">Hanne Sallinen</name></author><author><name sortKey="Yeh, Shin Joe" sort="Yeh, Shin Joe" uniqKey="Yeh S" first="Shin-Joe" last="Yeh">Shin-Joe Yeh</name></author><author><name sortKey="Wu, Teddy Y" sort="Wu, Teddy Y" uniqKey="Wu T" first="Teddy Y." last="Wu">Teddy Y. Wu</name></author><author><name sortKey="Ferrigno, Marc" sort="Ferrigno, Marc" uniqKey="Ferrigno M" first="Marc" last="Ferrigno">Marc Ferrigno</name></author><author><name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name></author><author><name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H. B. M." last="Schreuder">Floris H. B. M. Schreuder</name></author><author><name sortKey="Perry, Luke A" sort="Perry, Luke A" uniqKey="Perry L" first="Luke A." last="Perry">Luke A. Perry</name></author><author><name sortKey="Tanaka, Jun" sort="Tanaka, Jun" uniqKey="Tanaka J" first="Jun" last="Tanaka">Jun Tanaka</name></author><author><name sortKey="Boulanger, Marion" sort="Boulanger, Marion" uniqKey="Boulanger M" first="Marion" last="Boulanger">Marion Boulanger</name></author><author><name sortKey="Al Shahi Salman, Rustam" sort="Al Shahi Salman, Rustam" uniqKey="Al Shahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name></author><author><name sortKey="J Ger, Hans R" sort="J Ger, Hans R" uniqKey="J Ger H" first="Hans R." last="J Ger">Hans R. J Ger</name></author><author><name sortKey="Ambler, Gareth" sort="Ambler, Gareth" uniqKey="Ambler G" first="Gareth" last="Ambler">Gareth Ambler</name></author><author><name sortKey="Shakeshaft, Clare" sort="Shakeshaft, Clare" uniqKey="Shakeshaft C" first="Clare" last="Shakeshaft">Clare Shakeshaft</name></author><author><name sortKey="Yakushiji, Yusuke" sort="Yakushiji, Yusuke" uniqKey="Yakushiji Y" first="Yusuke" last="Yakushiji">Yusuke Yakushiji</name></author><author><name sortKey="Choi, Philip M C" sort="Choi, Philip M C" uniqKey="Choi P" first="Philip M. C." last="Choi">Philip M. C. Choi</name></author><author><name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name></author><author><name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name></author><author><name sortKey="Jeng, Jiann Shing" sort="Jeng, Jiann Shing" uniqKey="Jeng J" first="Jiann-Shing" last="Jeng">Jiann-Shing Jeng</name></author><author><name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name></author><author><name sortKey="Dowlatshahi, Dar" sort="Dowlatshahi, Dar" uniqKey="Dowlatshahi D" first="Dar" last="Dowlatshahi">Dar Dowlatshahi</name></author><author><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T." last="Engelter">Stefan T. Engelter</name></author><author><name sortKey="Parry Jones, Adrian R" sort="Parry Jones, Adrian R" uniqKey="Parry Jones A" first="Adrian R." last="Parry-Jones">Adrian R. Parry-Jones</name></author><author><name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name></author><author><name sortKey="Werring, David J" sort="Werring, David J" uniqKey="Werring D" first="David J." last="Werring">David J. Werring</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Anticoagulants (administration & dosage)</term><term>Cerebral Hemorrhage (drug therapy)</term><term>Cerebral Hemorrhage (mortality)</term><term>Cerebral Hemorrhage (pathology)</term><term>Cerebral Hemorrhage (surgery)</term><term>Female</term><term>Glasgow Coma Scale</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Multivariate Analysis</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Registries</term><term>Retrospective Studies</term><term>Survival Analysis</term><term>Treatment Outcome</term><term>Vitamin K (antagonists & inhibitors)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie orale</term><term>Analyse de survie</term><term>Analyse multivariée</term><term>Anticoagulants (administration et posologie)</term><term>Enregistrements</term><term>Femelle</term><term>Humains</term><term>Hémorragie cérébrale ()</term><term>Hémorragie cérébrale (anatomopathologie)</term><term>Hémorragie cérébrale (mortalité)</term><term>Hémorragie cérébrale (traitement médicamenteux)</term><term>Modèles de hasards proportionnels</term><term>Modèles logistiques</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Vitamine K (antagonistes et inhibiteurs)</term><term>Échelle de Glasgow</term><term>Études prospectives</term><term>Études rétrospectives</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Anticoagulants</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>Vitamin K</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Anticoagulants</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Vitamine K</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="mortality" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="mortalité" xml:lang="fr"><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Cerebral Hemorrhage</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Hémorragie cérébrale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Female</term><term>Glasgow Coma Scale</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Multivariate Analysis</term><term>Proportional Hazards Models</term><term>Prospective Studies</term><term>Registries</term><term>Retrospective Studies</term><term>Survival Analysis</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie orale</term><term>Analyse de survie</term><term>Analyse multivariée</term><term>Enregistrements</term><term>Femelle</term><term>Humains</term><term>Hémorragie cérébrale</term><term>Modèles de hasards proportionnels</term><term>Modèles logistiques</term><term>Mâle</term><term>Résultat thérapeutique</term><term>Échelle de Glasgow</term><term>Études prospectives</term><term>Études rétrospectives</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non–vitamin K antagonist oral anticoagulation–related ICH (NOAC-ICH) and vitamin K antagonist–associated ICH (VKA-ICH).</p></sec><sec><title>Methods:</title><p>We compared all-cause mortality within 90 days for NOAC-ICH and VKA-ICH using a Cox proportional hazards model adjusted for age; sex; baseline Glasgow Coma Scale score, ICH location, and log volume; intraventricular hemorrhage volume; and intracranial surgery. We addressed heterogeneity using a shared frailty term. Good functional outcome was defined as discharge modified Rankin Scale score ≤2 and investigated in multivariable logistic regression. ICH volume was measured by ABC/2 or a semiautomated planimetric method. HE was defined as an ICH volume increase >33% or >6 mL from baseline within 72 hours.</p></sec><sec><title>Results:</title><p>We included 500 patients (97 NOAC-ICH and 403 VKA-ICH). Median baseline ICH volume was 14.4 mL (interquartile range [IQR] 3.6–38.4) for NOAC-ICH vs 10.6 mL (IQR 4.0–27.9) for VKA-ICH (<italic>p</italic> = 0.78). We did not find any difference between NOAC-ICH and VKA-ICH for all-cause mortality within 90 days (33% for NOAC-ICH vs 31% for VKA-ICH [<italic>p</italic> = 0.64]; adjusted Cox hazard ratio (for NOAC-ICH vs VKA-ICH) 0.93 [95% confidence interval (CI) 0.52–1.64] [<italic>p</italic> = 0.79]), the rate of HE (NOAC-ICH n = 29/48 [40%] vs VKA-ICH n = 93/140 [34%] [<italic>p</italic> = 0.45]), or functional outcome at hospital discharge (NOAC-ICH vs VKA-ICH odds ratio 0.47; 95% CI 0.18–1.19 [<italic>p</italic> = 0.11]).</p></sec><sec><title>Conclusions:</title><p>In our international collaborative multicenter pooled analysis, baseline ICH volume, hematoma expansion, 90-day mortality, and functional outcome were similar following NOAC-ICH and VKA-ICH.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ruff, Ct" uniqKey="Ruff C">CT Ruff</name></author><author><name sortKey="Giugliano, Rp" uniqKey="Giugliano R">RP Giugliano</name></author><author><name sortKey="Braunwald, E" uniqKey="Braunwald E">E Braunwald</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ansell, J" uniqKey="Ansell J">J Ansell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schulman, S" uniqKey="Schulman S">S Schulman</name></author><author><name sortKey="Majeed, A" uniqKey="Majeed A">A Majeed</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Parry Jones, Ar" uniqKey="Parry Jones A">AR Parry-Jones</name></author><author><name sortKey="Di Napoli, M" uniqKey="Di Napoli M">M Di Napoli</name></author><author><name sortKey="Goldstein, Jn" uniqKey="Goldstein J">JN Goldstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Purrucker, Jc" uniqKey="Purrucker J">JC Purrucker</name></author><author><name sortKey="Haas, K" uniqKey="Haas K">K Haas</name></author><author><name sortKey="Rizos, T" uniqKey="Rizos T">T Rizos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hart, Rg" uniqKey="Hart R">RG Hart</name></author><author><name sortKey="Diener, Hc" uniqKey="Diener H">HC Diener</name></author><author><name sortKey="Yang, S" uniqKey="Yang S">S Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hankey, Gj" uniqKey="Hankey G">GJ Hankey</name></author><author><name sortKey="Stevens, Sr" uniqKey="Stevens S">SR Stevens</name></author><author><name sortKey="Piccini, Jp" uniqKey="Piccini J">JP Piccini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Held, C" uniqKey="Held C">C Held</name></author><author><name sortKey="Hylek, Em" uniqKey="Hylek E">EM Hylek</name></author><author><name sortKey="Alexander, Jh" uniqKey="Alexander J">JH Alexander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hagii, J" uniqKey="Hagii J">J Hagii</name></author><author><name sortKey="Tomita, H" uniqKey="Tomita H">H Tomita</name></author><author><name sortKey="Metoki, N" uniqKey="Metoki N">N Metoki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilson, D" uniqKey="Wilson D">D Wilson</name></author><author><name sortKey="Charidimou, A" uniqKey="Charidimou A">A Charidimou</name></author><author><name sortKey="Shakeshaft, C" uniqKey="Shakeshaft C">C Shakeshaft</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hallevi, H" uniqKey="Hallevi H">H Hallevi</name></author><author><name sortKey="Dar, Ns" uniqKey="Dar N">NS Dar</name></author><author><name sortKey="Barreto, Ad" uniqKey="Barreto A">AD Barreto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morgan, Tc" uniqKey="Morgan T">TC Morgan</name></author><author><name sortKey="Dawson, J" uniqKey="Dawson J">J Dawson</name></author><author><name sortKey="Spengler, D" uniqKey="Spengler D">D Spengler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dowlatshahi, D" uniqKey="Dowlatshahi D">D Dowlatshahi</name></author><author><name sortKey="Demchuk, Am" uniqKey="Demchuk A">AM Demchuk</name></author><author><name sortKey="Flaherty, Ml" uniqKey="Flaherty M">ML Flaherty</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhou, W" uniqKey="Zhou W">W Zhou</name></author><author><name sortKey="Zorn, M" uniqKey="Zorn M">M Zorn</name></author><author><name sortKey="Nawroth, P" uniqKey="Nawroth P">P Nawroth</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lauer, A" uniqKey="Lauer A">A Lauer</name></author><author><name sortKey="Cianchetti, Fa" uniqKey="Cianchetti F">FA Cianchetti</name></author><author><name sortKey="Van Cott, Em" uniqKey="Van Cott E">EM Van Cott</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Akiyama, H" uniqKey="Akiyama H">H Akiyama</name></author><author><name sortKey="Uchino, K" uniqKey="Uchino K">K Uchino</name></author><author><name sortKey="Hasegawa, Y" uniqKey="Hasegawa Y">Y Hasegawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hankey, Gj" uniqKey="Hankey G">GJ Hankey</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hart, Rg" uniqKey="Hart R">RG Hart</name></author><author><name sortKey="Boop, Bs" uniqKey="Boop B">BS Boop</name></author><author><name sortKey="Anderson, Dc" uniqKey="Anderson D">DC Anderson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Glund, S" uniqKey="Glund S">S Glund</name></author><author><name sortKey="Stangier, J" uniqKey="Stangier J">J Stangier</name></author><author><name sortKey="Schmohl, M" uniqKey="Schmohl M">M Schmohl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Siegal, Dm" uniqKey="Siegal D">DM Siegal</name></author><author><name sortKey="Curnutte, Jt" uniqKey="Curnutte J">JT Curnutte</name></author><author><name sortKey="Connolly, Sj" uniqKey="Connolly S">SJ Connolly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schiele, F" uniqKey="Schiele F">F Schiele</name></author><author><name sortKey="Van Ryn, J" uniqKey="Van Ryn J">J van Ryn</name></author><author><name sortKey="Canada, K" uniqKey="Canada K">K Canada</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pollack, Cv" uniqKey="Pollack C">CV Pollack</name></author><author><name sortKey="Reilly, Pa" uniqKey="Reilly P">PA Reilly</name></author><author><name sortKey="Eikelboom, J" uniqKey="Eikelboom J">J Eikelboom</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hofmeijer, J" uniqKey="Hofmeijer J">J Hofmeijer</name></author><author><name sortKey="Kappelle, Lj" uniqKey="Kappelle L">LJ Kappelle</name></author><author><name sortKey="Klijn, Cj" uniqKey="Klijn C">CJ Klijn</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sprigg, N" uniqKey="Sprigg N">N Sprigg</name></author><author><name sortKey="Renton, Cj" uniqKey="Renton C">CJ Renton</name></author><author><name sortKey="Dineen, Ra" uniqKey="Dineen R">RA Dineen</name></author><author><name sortKey="Kwong, Y" uniqKey="Kwong Y">Y Kwong</name></author><author><name sortKey="Bath, Pm" uniqKey="Bath P">PM Bath</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Anderson, Cs" uniqKey="Anderson C">CS Anderson</name></author><author><name sortKey="Heeley, E" uniqKey="Heeley E">E Heeley</name></author><author><name sortKey="Huang, Y" uniqKey="Huang Y">Y Huang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Al Shahi Salman, Rustam" sort="Al Shahi Salman, Rustam" uniqKey="Al Shahi Salman R" first="Rustam" last="Al-Shahi Salman">Rustam Al-Shahi Salman</name><name sortKey="Ambler, Gareth" sort="Ambler, Gareth" uniqKey="Ambler G" first="Gareth" last="Ambler">Gareth Ambler</name><name sortKey="Basir, Ghazala" sort="Basir, Ghazala" uniqKey="Basir G" first="Ghazala" last="Basir">Ghazala Basir</name><name sortKey="Boulanger, Marion" sort="Boulanger, Marion" uniqKey="Boulanger M" first="Marion" last="Boulanger">Marion Boulanger</name><name sortKey="Choi, Philip M C" sort="Choi, Philip M C" uniqKey="Choi P" first="Philip M. C." last="Choi">Philip M. C. Choi</name><name sortKey="Cordonnier, Charlotte" sort="Cordonnier, Charlotte" uniqKey="Cordonnier C" first="Charlotte" last="Cordonnier">Charlotte Cordonnier</name><name sortKey="Dowlatshahi, Dar" sort="Dowlatshahi, Dar" uniqKey="Dowlatshahi D" first="Dar" last="Dowlatshahi">Dar Dowlatshahi</name><name sortKey="Engelter, Stefan T" sort="Engelter, Stefan T" uniqKey="Engelter S" first="Stefan T." last="Engelter">Stefan T. Engelter</name><name sortKey="Ferrigno, Marc" sort="Ferrigno, Marc" uniqKey="Ferrigno M" first="Marc" last="Ferrigno">Marc Ferrigno</name><name sortKey="Houben, Rik" sort="Houben, Rik" uniqKey="Houben R" first="Rik" last="Houben">Rik Houben</name><name sortKey="J Ger, Hans R" sort="J Ger, Hans R" uniqKey="J Ger H" first="Hans R." last="J Ger">Hans R. J Ger</name><name sortKey="Jeng, Jiann Shing" sort="Jeng, Jiann Shing" uniqKey="Jeng J" first="Jiann-Shing" last="Jeng">Jiann-Shing Jeng</name><name sortKey="Meretoja, Atte" sort="Meretoja, Atte" uniqKey="Meretoja A" first="Atte" last="Meretoja">Atte Meretoja</name><name sortKey="Parry Jones, Adrian R" sort="Parry Jones, Adrian R" uniqKey="Parry Jones A" first="Adrian R." last="Parry-Jones">Adrian R. Parry-Jones</name><name sortKey="Perry, Luke A" sort="Perry, Luke A" uniqKey="Perry L" first="Luke A." last="Perry">Luke A. Perry</name><name sortKey="Purrucker, Jan C" sort="Purrucker, Jan C" uniqKey="Purrucker J" first="Jan C." last="Purrucker">Jan C. Purrucker</name><name sortKey="Rizos, Timolaos" sort="Rizos, Timolaos" uniqKey="Rizos T" first="Timolaos" last="Rizos">Timolaos Rizos</name><name sortKey="Sallinen, Hanne" sort="Sallinen, Hanne" uniqKey="Sallinen H" first="Hanne" last="Sallinen">Hanne Sallinen</name><name sortKey="Schreuder, Floris H B M" sort="Schreuder, Floris H B M" uniqKey="Schreuder F" first="Floris H. B. M." last="Schreuder">Floris H. B. M. Schreuder</name><name sortKey="Seiffge, David J" sort="Seiffge, David J" uniqKey="Seiffge D" first="David J." last="Seiffge">David J. Seiffge</name><name sortKey="Shakeshaft, Clare" sort="Shakeshaft, Clare" uniqKey="Shakeshaft C" first="Clare" last="Shakeshaft">Clare Shakeshaft</name><name sortKey="Sobowale, Oluwaseun A" sort="Sobowale, Oluwaseun A" uniqKey="Sobowale O" first="Oluwaseun A." last="Sobowale">Oluwaseun A. Sobowale</name><name sortKey="Staals, Julie" sort="Staals, Julie" uniqKey="Staals J" first="Julie" last="Staals">Julie Staals</name><name sortKey="Tanaka, Jun" sort="Tanaka, Jun" uniqKey="Tanaka J" first="Jun" last="Tanaka">Jun Tanaka</name><name sortKey="Traenka, Christopher" sort="Traenka, Christopher" uniqKey="Traenka C" first="Christopher" last="Traenka">Christopher Traenka</name><name sortKey="Veltkamp, Roland" sort="Veltkamp, Roland" uniqKey="Veltkamp R" first="Roland" last="Veltkamp">Roland Veltkamp</name><name sortKey="Werring, David J" sort="Werring, David J" uniqKey="Werring D" first="David J." last="Werring">David J. Werring</name><name sortKey="Wilson, Duncan" sort="Wilson, Duncan" uniqKey="Wilson D" first="Duncan" last="Wilson">Duncan Wilson</name><name sortKey="Wu, Teddy Y" sort="Wu, Teddy Y" uniqKey="Wu T" first="Teddy Y." last="Wu">Teddy Y. Wu</name><name sortKey="Yakushiji, Yusuke" sort="Yakushiji, Yusuke" uniqKey="Yakushiji Y" first="Yusuke" last="Yakushiji">Yusuke Yakushiji</name><name sortKey="Yeh, Shin Joe" sort="Yeh, Shin Joe" uniqKey="Yeh S" first="Shin-Joe" last="Yeh">Shin-Joe Yeh</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Asie/explor/AustralieFrV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000667 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000667 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Asie
|area= AustralieFrV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:5409844
|texte= Outcome of intracerebral hemorrhage associated with different oral anticoagulants
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28381513" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |